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German Ott
Professor of Pathology; Head Department of Clinical Pathology; Research Group Leader PharmacoOmics & Lymphoma

Prof. German Ott


Tel +49-711-8101-3390

Major Projects

  • The role of immunophenotypic variations and genetic/epigenetic alterations in FL and DLBCL tumors of patients treated within studies of the German Low Grade and High Grade Lymphoma Study Groups
  • Genetic and biologic alterations in MCL
  • The role of the Epstein-Barr Virus (EBV) in lympoproliferations of immunosuppressed and immunocompetent patients
  • Gene expression based survival model for patients with follicular lymphoma
  • Genetic polymorphisms in patients with follicular lymphoma
  • Molecular characterization of pleural mesotheliomas: investigation of cell cycle associated proteins in correlation with the status of p16INK4 and p14ARF.
  • Analysis of specific genetic alterations in routine formalin fixed paraffin-embedded tissues as an adjunct in the precise definition of malignant tumors (IZEPHA)

Selected References

Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E, Bhagat G, Borges AM, Boyer D, Calaminici M, Chadburn A, Chan JKC, Cheuk W, Chng WJ, Choi JK, Chuang SS, Coupland SE, Czader M, Dave SS, de Jong D, Du MQ, Elenitoba-Johnson KS, Ferry J, Geyer J, Gratzinger D, Guitart J, Gujral S, Harris M, Harrison CJ, Hartmann S, Hochhaus A, Jansen PM, Karube K, Kempf W, Khoury J, Kimura H, Klapper W, Kovach AE, Kumar S, Lazar AJ, Lazzi S, Leoncini L, Leung N, Leventaki V, Li XQ, Lim MS, Liu WP, Louissaint A Jr, Marcogliese A, Medeiros LJ, Michal M, Miranda RN, Mitteldorf C, Montes-Moreno S, Morice W, Nardi V, Naresh KN, Natkunam Y, Ng SB, Oschlies I, Ott G, Parrens M, Pulitzer M, Rajkumar SV, Rawstron AC, Rech K, Rosenwald A, Said J, Sarkozy C, Sayed S, Saygin C, Schuh A, Sewell W, Siebert R, Sohani AR, Tooze R, Traverse-Glehen A, Vega F, Vergier B, Wechalekar AD, Wood B, Xerri L, Xiao W. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Leukemia. 2022 Jul;36(7):1720-1748. doi: 10.1038/s41375-022-01620-2. Epub 2022 Jun 22.
Frontzek F, Staiger AM, Zapukhlyak M, Xu W, Bonzheim I, Borgmann V, Sander P, Baptista MJ, Heming JN, Berning P, Wullenkord R, Erdmann T, Lutz M, Veratti P, Ehrenfeld S, Wienand K, Horn H, Goodlad JR, Wilson MR, Anagnostopoulos I, Lamping M, Gonzalez-Barca E, Climent F, Salar A, Castellvi J, Abrisqueta P, Menarguez J, Aldamiz T, Richter J, Klapper W, Tzankov A, Dirnhofer S, Rosenwald A, Mate JL, Tapia G, Lenz P, Miething C, Hartmann W, Chapuy B, Fend F, Ott G, Navarro JT, Grau M, Lenz G. Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma. Nat Commun. 2021 Aug 31;12(1):5183. doi: 10.1038/s41467-021-25405-w.
Staiger AM, Hoster E, Jurinovic V, Winter S, Leich E, Kalla C, Möller P, Bernd HW, Feller AC, Koch K, Klapper W, Stein H, Hansmann ML, Hartmann S, Dreyling M, Weigert O, Hiddemann W, Herfarth K, Rosenwald A, Engelhard M, Ott G, Horn H. Localized- and advanced-stage follicular lymphomas differ in their gene expression profiles. Blood. 2020 Jan 16;135(3):181-190. doi: 10.1182/blood.2019000560.
Schmitz R, Wright GW, Huang DW, Johnson CA, Phelan JD, Wang JQ, Roulland S, Kasbekar M, Young RM, Shaffer AL, Hodson DJ, Xiao W, Yu X, Yang Y, Zhao H, Xu W, Liu X, Zhou B, Du W, Chan WC, Jaffe ES, Gascoyne RD, Connors JM, Campo E, Lopez-Guillermo A, Rosenwald A, Ott G, Delabie J, Rimsza LM, Tay Kuang Wei K, Zelenetz AD, Leonard JP, Bartlett NL, Tran B, Shetty J, Zhao Y, Soppet DR, Pittaluga S, Wilson WH, Staudt LM. Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma. N Engl J Med. 2018 Apr 12;378(15):1396-1407. doi: 10.1056/NEJMoa1801445.
Staiger AM, Ziepert M, Horn H, Scott DW, Barth TFE, Bernd HW, Feller AC, Klapper W, Szczepanowski M, Hummel M, Stein H, Lenze D, Hansmann ML, Hartmann S, Möller P, Cogliatti S, Lenz G, Trümper L, Löffler M, Schmitz N, Pfreundschuh M, Rosenwald A, Ott G; German High-Grade Lymphoma Study Group. Clinical Impact of the Cell-of-Origin Classification and the MYC/ BCL2 Dual Expresser Status in Diffuse Large B-Cell Lymphoma Treated Within Prospective Clinical Trials of the German High-Grade Non-Hodgkin's Lymphoma Study Group. J Clin Oncol. 2017 Aug 1;35(22):2515-2526. doi: 10.1200/JCO.2016.70.3660. Epub 2017 May 19.

Major Networks and Collaborations

  • Lymphoma/Leukemia Molecular Profiling Project (LLMPP)
  • Molecular Mechanisms in Malignant Lymphomas (MMML)
  • German Low Grade Lymphoma Study Group (GLSG)
  • German High Grade Lymphoma Study group (GHGLSG)

Education and Professional Career

4/2007-present

Professor of Pathology, Head of the Department of Clinical Pathology, Robert-Bosch Krankenhaus, Stuttgart, Germany

2006-2007

Full Professor, Cytopathology and Tumor Genetics at the Institute of Pathology, University of Würzburg, Germany

1998-2006

Staff Pathologist and Associate Professor at the Institute of Pathology, University of Würzburg, Germany

1990-1998

Postdoctoral Fellow and Pathologist in training at the Institute of Pathology, University of Würzburg, Germany

1988-1990

Postdoctoral Fellow at the Department of Pathology, Technical University of Aachen, Germany

Professional Memberships

  • European Association of Haematopathology
  • Berufsverband Pathologie
  • International Academy of Pathology

Scientific Journal Editorial Board Memberships

  • Annals of Hematology
  • Journal of Haematopathology
  • Journal of Clinical Oncology

Research Group

PharmacoOmics & Lymphoma