Dr. Werner Schroth | Institut für klinische Pharmakologie IKP

Major Projects

Pharmacogenomics of breast cancer
Hormone-sensitive trial exploration for novel treatment predictors
Prospective study: supplementation of standard TAMoxifen with ENDOXifen
Estrogen receptor regulation and signaling
Early detection: Liquid biopsy in adjuvant settings, tumor profiling

Selected References

Khor, C. C. et al. Cross‐Ancestry Genome‐Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations. Clin Pharmacol Ther 113, 712–723 (2023)

Almeida, T. et al. (Z)-Endoxifen and Early Recurrence of Breast Cancer: An Explorative Analysis in a Prospective Brazilian Study. J Personalized Medicine 12, 511 (2022)

Schroth, W. et al. Gene Expression Signatures of BRCAness and Tumor Inflammation Define Subgroups of Early-Stage Hormone Receptor–Positive Breast Cancer Patients. Clin Cancer Res 26, 6523–6534 (2020)

Mohr, C. J. et al. Subunits of BK channels promote breast cancer development and modulate responses to endocrine treatment in preclinical models. Brit J Pharmacol 179, 2906–2924 (2020)

Brauch, H., Schroth, W., Mürdter, T. & Schwab, M. Tamoxifen Pharmacogenetics and Metabolism: The Same Is Not the Same. J Clin Oncol 37, 1981–1982 (2019)

Major Networks and Collaborations, Funding

International Tamoxifen Pharmcogenomics Consortium (ITPC)
Marie Curie Initial Training Network (ITN) „FightingDrugFailure: Priorities and Standards in Phamacogenomic Research: Opportunities for a Safer and More Efficient Pharmacotherapy“
Funded by German Research Council (DFG), German Federal Ministry of Education and Research (BMBF), Interfaculty Center for Pharmacogenomics and Drug Research (ICEPHA), Tübingen, Germany

Curriculum Vitae

Education and Professional Career

Since 2021

Group leader “Breast cancer” at Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology

Since 2004

Scientist in oncology research ‘pharmacogenomics and molecular profiling of breast cancer’, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Prof. H. Brauch, IKP Stuttgart, Germany

2000-2003

Consultant & scientist-in-charge ‘autoimmune diagnostics’, Dermatological Institute, Prof P. Kind, Offenbach, Germany

2001-2003

Post-doctoral position, ‘evolution of homeobox genes in lower metazoans’, Prof B. Schierwater, ITZ Hannover, Germany

2000

PhD degree at J.W.Goethe University, Frankfurt, Germany: speciation and environmental monitoring in moon jellyfish

1999-2000

Research Fellowship Deutsche Bundesstiftung Umwelt DBU

1997-2000

Dissertation at J.W.Goethe University, Frankfurt, Germany

1996-1998

Employment DFG project ‘microsatellites paternity analyses’, J.W.Goethe University

1996

Environmental Research Award, J.W.Goethe University

1995

Diploma in Biology at J.W.Goethe University, Frankfurt, Germany: population genetics in sea turtles

1987-1994

Study of Biology, J.W.Goethe University, Frankfurt, Germany

Professional Memberships

Affiliate membership: American Association for Cancer Research AACR

Research Group

PharmacoOmics & Breast Cancer

> Core Facility
Molecular Analytics