Ute Hofmann2

Chemical Analytics & Synthesis (retired 2024)

Dr. Ute Hofmann

Tel +49-711-8101-5907

ute.hofmann@ikp-stuttgart.de

PubMed

Major Projects

Mass spectrometry-based targeted metabolomics and lipidomics
Drug metabolism
Development of analytical methods

Selected References

Lackner M, Neef SK, Winter S, Beer-Hammer S, Nürnberg B, Schwab M, Hofmann U, Haag M. Untargeted stable isotope-resolved metabolomics to assess the effect of PI3Kβ inhibition on metabolic pathway activities in a PTEN null breast cancer cell line. Front Mol Biosci. 2022 Oct 14;9:1004602.

Pristup J, Schaeffeler E, Arjune S, Hofmann U, Angel Santamaria-Araujo J, Leuthold P, Friedrich N, Nauck M, Mayr S, Haag M, Muerdter T, Marner FJ, Relling MV, Evans WE, Schwarz G, Schwab M. Molybdenum Cofactor Catabolism Unravels the Physiological Role of the Drug Metabolizing Enzyme Thiopurine S-Methyltransferase. Clin Pharmacol Ther. 2022 Oct;112(4):808-816.

Ghallab A, Hassan R, Hofmann U, Friebel A, Hobloss Z, Brackhagen L, Begher-Tibbe B, Myllys M, Reinders J, Overbeck N, Sezgin S, Zühlke S, Seddek AL, Murad W, Brecklinghaus T, Kappenberg F, Rahnenführer J, González D, Goldring C, Copple IM, Marchan R, Longerich T, Vucur M, Luedde T, Urban S, Canbay A, Schreiter T, Trauner M, Akakpo JY, Olyaee M, Curry SC, Sowa JP, Jaeschke H, Hoehme S, Hengstler JG. Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity. J Hepatol. 2022 Jul;77(1):71-83.

Heintze T, Wilhelm D, Schmidlin T, Hofmann U, Zanger UM, Schwab M, Klein K. Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis. Front Pharmacol. 2021 Nov 15;12:769703.

Ghallab A, Hofmann U, Sezgin S, Vartak N, Hassan R, Zaza A, Godoy P, Schneider KM, Guenther G, Ahmed YA, Abbas AA, Keitel V, Kuepfer L, Dooley S, Lammert F, Trautwein C, Spiteller M, Drasdo D, Hofmann AF, Jansen PLM, Hengstler JG, Reif R. Bile micro-infarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood. Hepatology. 2019 Feb;69(2):666-683.

Major Networks and Collaborations

Member of LiSym (Liver Systems Medicine) funded by the BMBF

Extramural Funding

BMBF (Federal Ministry of Education and Research) Virtual Liver Network for systems biology of the liver

Curriculum Vitae

Education and Professional Career

Since 6/1992

Head of the Department of Analytical Chemistry at the Dr. Margarete Fischer-Bosch-Institute

Since 2/1987

Scientist at the Dr. Margarete Fischer-Bosch-Institute for Clinical Pharmacology, Stuttgart

1984–1986

Ph.D. at the Institute of Organic Chemistry, University of Stuttgart, under supervision of Prof. P. Fischer

1977–1984

Studies in chemistry, University of Stuttgart, Stuttgart, Germany

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