Dr. Kathrin Klein | Institut für klinische Pharmakologie IKP

Major Projects

Tissue “Biobank”:Liver
Inter- and intraindividual expression variability of ADME genes
Pharmacogenomics and Pharmacogenetics of Cytochrome P450s
Genomewide analysis of Polymorphisms and Gene Expression in Human Liver
Cell culture systems for hepatic pharmacogenetics research

Selected References

Desta, Z., El-Boraie, A., Gong, L., Somogyi, A. A., Lauschke, V. M., Dandara, C., Klein, K., Miller, N., Klein, T. E., Tyndale, R. F., Whirl-Carrillo, M., and Gaedigk, A. PharmVar GeneFocus: CYP2B6. Clin Pharmacol Ther (2021).

Heintze, T., Klein, K., Hofmann, U., and Zanger, U. M. Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells. Sci Rep 11:1, 1000 (2021).

Zanger, U. M., Momoi, K., Hofmann, U., Schwab, M., and Klein, K. Tri-Allelic Haplotypes Determine and Differentiate Functionally Normal Allele CYP2D6*2 and Impaired Allele CYP2D6*41. Clin Pharmacol Ther (2020).

Klein, K., Tremmel, R., Winter, S., Fehr, S., Battke, F., Scheurenbrand, T., Schaeffeler, E., Biskup, S., Schwab, M., and Zanger, U. M. A New Panel-Based Next-Generation Sequencing Method for ADME Genes Reveals Novel Associations of Common and Rare Variants With Expression in a Human Liver Cohort. Front Genet 10, 7 (2019).

Thomas, M., Winter, S., Nussler, A. K., Niemi, M., Schwab, M., and Zanger, U. M. PPARA A novel genetic determinant of CYP3A4 in vitro and in vivo. Clin. Pharmacol. Ther. 91:6, 1044–1052 (2012).

Curriculum Vitae

Education and Professional Career

1999 - present

Postdoctoral fellow at Institute of Clinical Pharmacology in the Department of Pharmacogenetics

1996-1998

Incentive Program of the Baden-Württemberg Ministry of Education and Science: Südzucker AG / Institute of Industrial Genetics: “Development of genetic methods to optimize the Palatinose yield using Saccharose-Mutase from P.rubrum”

1990-1995

PhD (Institute of Industrial Genetics, University Suttgart) “Die Bedeutung von Saccharose-Stoffwechselgenen für die Bakterielle Isomaltulose-Herstellung”

1989

Diploma Thesis (Institute of Biology, Biophysics department, University Stuttgart) “Zellzyklusanalysen an Monolayerkulturen und Multizellsphäroiden”

1984-1988

Study of Biology at the University of Stuttgart

Professional Memberships

Since 2009: Member of International Society for the Study of Xenobiotics (ISSX)
Since 2019: Member of the Pharmacogene Variation Consortium (PharmVar)

Scientific Journal Editorial Board Memberships

Associate Editor of Frontiers in Pharmocogenetics

Research Group

Education & Training

> Core Facility
Pharmacological Warehouse