Pharmacometrics is the science of interpreting and understanding pharmacology quantitatively. It involves applying mathematical and statistical models to pharmacological data, supporting decision-making in drug development, regulatory submissions, and clinical practice. Moreover, pharmacometrics is used to optimize drug therapy and dosing regimens for diverse patient populations including children, the elderly or patients with specific conditions such as renal or hepatic impairment or cancer. Pharmacometricians use a variety of modeling techniques to simulate clinical trials, reducing the need for expensive and time-consuming clinical or preclinical trials and aiding in the understanding of complex biological systems. Key pharmacometric methods include population pharmacokinetics (PopPK), pharmacokinetics/pharmacodynamics (PK/PD) modeling, and physiologically-based pharmacokinetic (PBPK) modeling. The insights gained from pharmacometric analyses help in optimizing dosing, enhancing drug efficacy, and minimizing adverse effects facilitating more personalized medicine.