Dr. rer. nat. Oliver Burk | Institut für klinische Pharmakologie IKP

Major Projects

Molecular mechanisms of the interindividual variability in expression and induction of ABCB1
Molecular mechanisms of gene regulation of drug transporters by NRs
Identification of proteins interacting with PXR/CAR
Comparative genomics of ADME gene regulation
Role of PXR/CAR in human non-alcoholic fatty liver disease

Selected References

Mustonen EK, Pantsar T, Rashidian A, Reiner J, Schwab M, Laufer S, Burk O. Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library. Cells. 2022 Apr 12;11(8):1299

Burk O, Kronenberger T, Keminer O, Lee SML, Schiergens TS, Schwab M, Windshügel B. Nelfinavir and Its Active Metabolite M8 Are Partial Agonists and Competitive Antagonists of the Human Pregnane X Receptor. Mol Pharmacol. 2021 Mar;99(3):184-196.

Burk O, Kuzikov M, Kronenberger T, Jeske J, Keminer O, Thasler WE, Schwab M, Wrenger C, Windshügel B. Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles. Arch Toxicol. 2018 Apr;92(4):1435-1451

Jeske J, Bitter A, Thasler WE, Weiss TS, Schwab M, Burk O. Ligand-dependent and -independent regulation of human hepatic sphingomyelin phosphodiesterase acid-like 3A expression by pregnane X receptor and crosstalk with liver X receptor. Biochem Pharmacol. 2017 Jul 15;136:122-135.

Bitter A, Rümmele P, Klein K, Kandel BA, Rieger JK, Nüssler AK, Zanger UM, Trauner M, Schwab M, Burk O. Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms. Arch Toxicol. 2015 Nov;89(11):2089-103.

Major Networks and Collaborations

Prof. Leszek Wojnowski, Institute of Pharmacology, Johannes Gutenberg Universität, Mainz, Germany
José Pedro Gil, Karolinska Institute, Stockholm, Sweden

Curriculum Vitae

Education and Professional Career

2007-present

Research group leader in the research division “Pharmacogenomics” of Prof. Dr. Matthias Schwab at the Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany. Area of research: “Molecular mechanisms of ADME gene regulation”

2000-2006

Reseach group leader in the research division “Pharmacogenomics” of Prof. Dr. Michel Eichelbaum at the Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany. Area of research: “Gene regulation of drug metabolizing enzymes and transporters by nuclear receptors”

1997-1999

Postdoctoral research fellow in the research group of Prof. Dr. Hermann Wisser, Robert Bosch Hospital, Stuttgart, Germany. Research topic: “Age-dependent differential gene expression in the heart”

1993-1997

Postdoctoral research fellow in the laboratory of PD Dr. Karl-Heinz Klempnauer at the Max-Planck-Institute of Immunobiology, Freiburg, Germany, (within SFB 364: Molecular and cellular basis of tumor therapy); Research topic: “Identification of myb-regulated genes in haematopoiesis”

1993

Dr. rer. nat. (PhD), Faculty of Biology, Justus-Liebig University Giessen, Germany

1989-1993

PhD thesis in the laboratory of PD Dr. Karl-Heinz Klempnauer, first at the Center of Molecular Biology Heidelberg (ZMBH), since 1990 at the Max-Planck-Institute of Immunobiology, Freiburg, Germany. Title of the thesis: “Investigation of the regulation of myeloid-specific gene expression by the sequence-specific transcription factor v-myb”

1986-1987

Diploma thesis at the Institute of Genetics (Prof. Dr. Fritz Anders), Justus-Liebig University Giessen, Germany. Title of the thesis: “Conservation of homologues sequences of the nuclear protein-coding oncogenes v-fos, v-myc and v-myb in the animal kingdom”

1981-1987

Study of Biology at the Justus-Liebig University Giessen, Germany.

Professional Memberships

since 2000: International Society for the Study of Xenobiotics (ISSX)
since 2001: German Society for Biochemistry and Molecular Biology (Gesellschaft für Biochemie und Molekularbiologie (GBM))
since 2002: American Society for Biochemistry and Molecular Biology (ASBMB)

Scientific Journal Editorial Board Memberships

Frontiers in Pharmacogenetics

Research Group

Transport & Nuclear Receptors

Dr. Oliver Burk